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Anatomical Pathology

GASTROPATHOLOGY

GASTROPATHOLOGY

In HRP Labs we are distinguished by our division of Gastropathology and Hepatic Pathology…

HEMATOPATHOLOGY

HEMATOPATHOLOGY

We have a complete department of hematopathology directed by Dr. Dana Delgado, FCAP…

DERMATOPATHOLOGY OF THE SKIN

DERMATOPATHOLOGY OF THE SKIN

Comprehensive pathological diagnostic service that evaluates inflammatory and neoplastic conditions…

NEUROPATHOLOGY

NEUROPATHOLOGY

The neuropathology service offers specialized interpretation of neurosurgical biopsies…

IMMUNOPATHOLOGY

IMMUNOPATHOLOGY

We provide a wide variety of diagnostic immunohistochemical panels that assist the pathologist in their diagnosis. 

MOLECULAR PATHOLOGY

MOLECULAR PATHOLOGY

Our technicians, licensed by the College of Medical Technologists of Puerto Rico, work with molecular test panels that give physicians the opportunity to identify more effective treatment options that specifically target your patient’s type of cancer.

BREAST PATHOLOGY

BREAST PATHOLOGY

Our services encompass the full spectrum of testing in the diagnosis and management of breast diseases.

UROLOGY, KIDNEY AND URINE CYTOLOGY

UROLOGY, KIDNEY AND URINE CYTOLOGY

We have a select group of pathologists with vast experience in studies of prostate tissues…

GASTROPATHOLOGY

In HRP Labs we are distinguished by our division of Gastropathology and Hepatic Pathology, with more than 15 years of experience, directed by Dr. Kathia Rosado, MD, FCAP. We have an “in-house” Immunohistochemical laboratory to obtain your results as soon as possible, without sacrificing the quality of your diagnoses.

These services include:

  • Processing, diagnosis and interpretation of biopsies and surgical specimens
  • Intraoperative consultations
  • Review oflamellae and second opinions of cases performed in other laboratories
  • Services of immunohistochemistry and immunopathology including the determination of:
  • MSI (Micro Satellite Instability) by immunohistochemistry for adenomas or adenocarcinomas (MLH-6, PSM-2, MLH-1, MSH-2)
  • Special dyes
  • Molecular pathology to determine mutations in KRAS, BRAF and EGFR genes and thus to determine targeted therapy.

HEMATOPATHOLOGY

We have a complete department of hematopathology directed by Dr. Dana Delgado, FCAP, sub specialty in Hematopathology. In this way, a greater number of samples are processed and diagnosed locally at a cost that responds to the rates and prices established in our community, reducing the need to use laboratories outside of Puerto Rico.

“In-House” Hematopathology Tests

  • Immunohistochemistry
  • FISH (Tissue block only)
  • ISH (EBER)
  • Flow cytometry
  • Expanded bone marrow aspirates
  • Extending peripheral blood

 

Available through our Reference Laboratory:

  • FISH in fresh / liquid tissues
  • Cytogenetics
  • BCR-ABL Screening (p190 + p210) 
  • by Quantitative
  • BCR-ABL PCR (p190 OR p210)
  • – Previous positive report required
  • JAK 2 (V617F) mutation
  • JAK 2 EXON 12 mutation
  • MPL mutation
  • Calreticulin
  • MYD88
  • KIT D816V
  • Mutation CEBPA
  • MUTATION FLT3
  • Mutation NPMl
  • PML-RARA by PCR (S TAT cases)
  • B-cell gene rearrangement (IgH)
  • B-cell gene rearrangement (IgK)
  • T-cell gene rearrangement (beta)
  • T-cell gene rearrangement (gamma)

For Specimen Shipment Requirements click here.

DERMATOPATHOLOGY

Comprehensive pathological diagnostic service that evaluates inflammatory and neoplastic conditions of the skin for the prevention and recommendation of treatments.

  • Special dyes
  • Detection of dermatophytes
  • Evaluation of margins
  • Sections in frozen
  • Cultures for fungi
  • Skin lesions, neoplastic and inflammatory.
  • Immunohistochemistry
  • Mutation tests in BRAF

NEUROPATHOLOGY

The neuropathology service offers specialized interpretation of neurosurgical biopsies. Additionally, it provides consulting services for brain, skeletal muscle and nerve biopsies. The consultancy also includes autopsy material.

These studies include:

  • Conventional and special histological staining techniques.
  • Immunohistochemistry
  • In situ hybridization

Tests performed:

  • Brain biopsies and autopsies
  • Intraoperative diagnosis of cytological smears and freezing cuts
  • Study of tissues included in paraffin and stained with Hematoxylin and Eosin

In Situ Hybridization:

  • Analysis of alterations of1p / 19q.
  • Muscle Biopsies
  • Systematic study of muscular diseases, including inflammatory myopathies, congenital myopathies, muscular dystrophies and denervation myopathies.
  • Fabric Processed in slices by freezing: H / E; ATPase (acid and alkaline), NADH, Trichrome, PAS, Oil Red, COX, SDH.
  • Paraffin embedded fabric: H / E and special stains as needed.
  • Immunohistochemistry (paraffin and freeze cuts): Myosin (fast & slow), Dystrophin Panel, Sarcoglycan Panel, Dysferlin, Inflammatory Panel (MHC Class I, LCA, CD68, CD3, CD4, CDS, CD20)

** Note: Muscle biopsies are performed through prior coordination with our department, according to the established protocol.

IMMUNOPATHOLOGY SERVICES

With 20 years of experience, Dr. Luis E. Ferrer, certified in anatomical and clinical pathology, directs the department of immunopathology.

Wide variety of diagnostic immunohistochemical panels that assist the pathologist in their diagnosis:

  • Carcinomas of unknown origin
  • (CUP)
  • Lymphomas and leukemias
  • Melanomas
  • Lung carcinomas
  • Neuroendocrine carcinomas
  • Hepatic carcinomas
  • Renal carcinomas
  • Soft tissue sarcomas
  • Basal cells (breast and prostate)
  • e-Cadherin (breast carcinomas)
  • In-Situ Hybridization (ISH)
  • Deletion of lp / 19q
  • Her2 /neu
  • HPVScreen
  • EBER
  • IgH (14q32)
  • BCL2 (18q21)
  • MYC (8q24)
  • MALTl (18q32)
  • BCR (22q11)
  • ALK ROSl
  • Immunofluorescence studies
  • Cutaneous
  • Kidney
  • Transplants
  • KRAS mutation analysis
  • BRAF mutation analysis
  • EGFR mutation analysis
  • Flow Cytometry for the determination of leukemias
    and lymphomas
  • Bone marrow
  • Cerebrospinal fluid
  • Fine Needle Aspiration (FNA)
  • Body fluids (pleural, peritoneal, among others)
  • Immunoperoxidase

MOLECULAR PATHOLOGY

Our technicians, licensed by the College of Medical Technologists of Puerto Rico, work focused on the detection of:

  • Genotyping of human
  • papillomavirus (HPV)
  • Vaginal
  • Anal
  • Chlamydia and Gonorrhea
  • Tests of Fetal Fibronectin (Ffn)
  • In-Situ Hybridization with Fluorescence (FISH)
  • UroVysion (FISH)
  • Detection of bladder cancer
  • BRAF mutation analysis
  • KRAS mutation analysis
  • EGFR mutation analysis

BREAST PATHOLOGY

Services for the detection of breast cancer:

  • Surgical analysis and diagnosis
  • Needle biopsies (“core needle biopsy”)
  • Fine Needle Biopsy (FNA)
  • Mastectomy
  • Lumpectomy
  • Sentinel nodules
  • Immunohistochemistry services (IHC)
  • Prognostic factors – ER, PR, Herz/ neu, Ki -67, p53
  • Determination of myoepithelial cells to diagnose proliferative epitheclial processes
  • Ductal carcinoma vs. Lobular
  • Confirmation of HERZ/ neu status using molecular tests
  • Herz/ neu by FISH
  • OncotypeDx and Mammaprint (reference laboratories)

UROLOGY

We have a select group of pathologists with vast experience in studies of prostate tissues, kidney and urine cytology.

Biopsies:

  • Prostate
  • Kidney
  • Barbotage
  • Catheterized

Urine Cytologies:

  • Barbotage
  • Catheterized PCA3 (Prostate
  • Cancer in Gen 3) in urine
  • Voided urine

Molecular Tests:

  • Urovysion-FISH
  • Genotyping HPV
  • Chlamydia and Gonorrhea

Ancillary Tests:

  • PIN 4

Prognostic Markers:

  • ERG (if positive for adenocarcinoma)
  • Panel for prostate biopsies

Urine cytologies:

  • Barbotage
  • Catheterized